why can’t some hair be combed?

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Some children have problems with completely tangled hair, which, as their parents will attest, can not be combed at all.

In German, the phenomenon bears the apt name “uncombable hair syndrome” or even “Struwwelpeter syndrome. ”



Now, researchers have identified mutations in three genes responsible – a discovering that could pave the way for an actual clinical diagnosis of uncombable hair.

Two – named PADI3 and TGM3 – support the assembly guidelines for enzymes, while the third, TCHH, carries an important protein for the hair shaft.

In healthier hair, the TCHH proteins are joined to each other with extremely fine strands of keratin, which are in charge of the shape and structure of the hair.

During this process, the two other identified genes play a significant role – PADI3 changes the hair shaft protein TCHH so that the keratin filaments can abide by it, and the TGM3 enzyme then produces the actual link.


The international team of scientists behind the new study, just published in the American Journal of Human Genetics, say a huge amount could possibly be learned about the newfound mechanisms involved in forming healthy hair, and why disorders sometimes occur.

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